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2023-06-01
Prospective evaluation of the efficacy, safety, and the optimal biomarker enrichment strategy for nangibotide, a TREM-1 inhibitor, in patients with septic shock: a double-blind, randomized, controlled, phase 2b trial. The Lancet Respiratory Medicine
2023-06-01
Evaluation of the efficacy and safety of TREM-1 inhibition with nangibotide in patients with COVID19 receiving respiratory support: results of the ESSENTIAL randomized, double-blind trial. eClinicalMedicine
2021-07-22
Increased sTREM-1 plasma concentrations are associated with poor clinical outcomes in patients with COVID-19. Bioscience Reports
2021-06-01
Rationale and protocol for the efficacy, safety and tolerability of nangibotide in patients with septic shock (ASTONISH) phase IIb randomised controlled trial. BMJ Open
2021-01-13
Potentiation of NETs release is novel characteristic of TREM-1 activation and the pharmacological inhibition of TREM-1 could prevent from the deleterious consequences of NETs release in sepsis. Cellular and Molecular Immunology
2020-05-25
Nangibotide in patients with septic shock: a Phase 2a randomized controlled clinical trial. Intensive Care Medicine.
2020-03-24
High STREM-1 levels and low monocyte HLA-DR expression are associated with nosocomial infections and mortality in septic shock patients. Critical Care
2019-11-27
The SOFA score—development, utility and challenges of accurate assessment in clinical trials. Critical Care
2018-10-02
Safety and pharmacodynamic activity of a novel TREM-1 pathway inhibitory peptide in septic shock patients: phase IIa clinical trial results. Intensive Care Medicine Experimental.
2018-06-09
A first-in-man safety and pharmacokinetics study of nangibotide, a new modulator of innate immune response through TREM-1 receptor inhibition. British Journal of Clinical Pharmacology.
2018-06-07
Review : TREM-1; Is It a Pivotal Target for Cardiovascular Diseases? Journal of Cardiovascular Development and Disease
2018-03-22
TREM-1 multimerization is essential for its activation on monocytes and neutrophils. Cellular and Molecular Immunology.
2018-03-20
Roche Sees « New Front in Critical Care Medicine » With CDx Deal Aimed at Septic Shock. GenomeWeb.
2018-01-19
Targeted endothelial gene deletion of Triggering Receptor Expressed on Myeloid cells-1 protects mice during septic shock. Cardiovasc Res.
2017-08-03
TREM-1 SNP rs2234246 regulates TREM-1 protein and mRNA levels and is associated with plasma levels of L-selectin. PLoS ONE.
2017-07-27
Triggering Receptor Expressed on Myeloid cells-1: a new player in platelet aggregation. Thrombosis and Haemostasis.
2017-05-01
LR12-peptide quantitation in whole blood by RP-HPLC and intrinsic fluorescence detection: Validation and pharmacokinetic study. Biomedical Chromatography.
2017-02-27
TREM-1 and its potential ligands in non-infectious diseases: from biology to clinical perspectives. Pharmacological Research
2016-12-27
Genetic and Pharmacological Inhibition of TREM-1 Limits the Development of Experimental Atherosclerosis. Journal of the American College of Cardiology. Inotrem collaborated in this study with Pr Hafid Ait Oufella from team 5 of the the Paris Cardiovascular Research Center (PARCC) to demonstrate the role of TREM-1 in the development of atherosclerosis.
2015-10-30
The Triggering Receptor Expressed on Myeloid cells-1: A new player during acute myocardial infarction. Pharmacological Research
2015-06-20
Pharmacological inhibition of the triggering receptor expressed on myeloid cells-1 limits reperfusion injury in a porcine model of myocardial infarction. ESC Heart Failure.
2015-05-22
TREM-1 Mediates Inflammatory Injury and Cardiac Remodeling Following Myocardial Infarction. Circulation Research. Inotrem published here new results demonstrating the role of TREM-1 during the pathophysiology of acute myocardial infarction. We are really proud of this disruptive paper showing for the first time the role of TREM-1 in cardiovascular setting
2014-04-15
Attenuation of responses to endotoxin by the triggering receptor expressed on myeloid cells-1 inhibitor LR12 in nonhuman primate. Anesthesiology
2013-02-15
Effects of a TREM-like transcript 1-derived peptide during hypodynamic septic shock in pigs. Shock.
2012-06-01
Soluble TREM-like transcript-1 regulates leukocyte activation and controls microbial sepsis. The Journal of Immunology.
2010-07-20
Triggering receptor expressed on myeloid cells-1 as a new therapeutic target during inflammatory diseases. Self/Non-Self.